PhD student early lung cancer detection with CT: subsolid pulmonary nodules


Job description

Lung cancer is the most deadly cancer in men and women. Because most patients are diagnosed when the disease is already in an advanced stage, the 5-year survival rate is poor. With the advent of new generations multi-slice CT scanners, and their use in trials for lung cancer screening, we have learned that around 40% of all lung cancers have an early stage in which they are visible as a subsolid nodule on CT scans. If such precancerous lesions and early lung cancers are treated, survival rates approach 100%. But a too agressive management of such lesions also has risks. It may lead to overdiagnosis and overtreatment.

The goal of this project is to investigate the prevalence, malignancy rate, and long term outcome of subsolid nodules found on chest CT. Morphological characteristics, assessed by humans and by advanced computer analysis algorithms, that can predict malignancy and risk for death from lung cancer will be identified. The ultimate goal is to identify these incidental findings on chest CT that would lead to morbidity and mortality if left untreated, at a time when cure is possible and subsequent death from cancer can be avoided.

We are looking for an ambitious PhD student to work on this three year project that is funded by the Dutch Cancer Foundation. The work should result in a PhD thesis. This project is a collaboration between the Department of Radiology of Radboud University Nijmegen Medical Centre and the Department of Radiology of University Medical Center Utrecht, and the Diagnostic Image Analysis Group.

Your profile

  • MSc degree (or equivalent) in Medicine
  • Strong interest in radiology and oncological research
  • Excellent communication skills in English, interest and capabilities to work in an interdisciplinary research team

Radboud University Nijmegen Medical Centre

Nijmegen is the oldest Dutch city with a rich history and one of the liveliest city centers in the Netherlands. Radboud University has over 17,000 students. Radboud University Nijmegen Medical Centre (RUNMC) is a leading academic center for medical science, education and health care with over 8,500 staff and 3,000 students.

Terms of employment for PhD students

You will be appointed as a clinical PhD student at the Radboud University Medical Center Nijmegen, Department of Radiology, with the standard salary and secondary conditions for clinical PhD students in the Netherlands. You will work within the Institute for Oncology of Radboud University Nijmegen Medical Centre. Your performance will be evaluated after 1 year and will normally be extended by 2 years.


For further information please contact Cornelia Schaefer-Prokop or Eva van Rikxoort.


Send your application via this link.